Kenneth R Chapman Selected Research

alpha 1-Antitrypsin (alpha 1 Antitrypsin)

1/2018	Alpha 1 antitrypsin to treat lung disease in alpha 1 antitrypsin deficiency: recent developments and clinical implications.
1/2017	Long-term efficacy and safety of α1 proteinase inhibitor treatment for emphysema caused by severe α1 antitrypsin deficiency: an open-label extension trial (RAPID-OLE).
7/2015	Intravenous augmentation treatment and lung density in severe α1 antitrypsin deficiency (RAPID): a randomised, double-blind, placebo-controlled trial.

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Kenneth R Chapman Research Topics

Disease

43	Chronic Obstructive Pulmonary Disease (COPD) 10/2021 - 03/2002
36	Asthma (Bronchial Asthma) 01/2022 - 03/2002
9	Inflammation (Inflammations) 01/2020 - 01/2003
6	Emphysema 01/2018 - 01/2005
5	Obstructive Lung Diseases (Obstructive Lung Disease) 01/2022 - 03/2002
5	Dyspnea (Shortness of Breath) 01/2016 - 01/2012
4	Disease Progression 01/2018 - 01/2017
3	Pneumonia (Pneumonitis) 01/2017 - 07/2015
2	COVID-19 12/2020 - 01/2020
2	Lung Diseases (Lung Disease) 01/2018 - 07/2009
2	Eosinophilia 11/2017 - 08/2010
1	Airway Obstruction (Choking) 10/2021
1	Body Weight (Weight, Body) 05/2021
1	Respiratory Tract Diseases (Respiratory Tract Disease) 12/2020
1	Confusion (Bewilderment) 06/2019
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2019
1	Peripheral Arterial Disease 01/2018
1	alpha 1-Antitrypsin Deficiency (alpha 1 Antitrypsin Deficiency) 01/2018
1	Hypertension (High Blood Pressure) 11/2017
1	Heart Failure 11/2017
1	Chronic Renal Insufficiency 11/2017
1	Ocular Hypertension (Glaucoma, Suspect) 02/2017
1	Open-Angle Glaucoma (Glaucoma, Open Angle) 02/2017
1	Aplastic Anemia (Anemia, Hypoplastic) 10/2016
1	Pulmonary Eosinophilia (Eosinophilic Pneumonia) 10/2016
1	IgA Deficiency 07/2015
1	Respiratory Insufficiency (Respiratory Failure) 07/2015
1	Sepsis (Septicemia) 07/2015
1	Breast Neoplasms (Breast Cancer) 07/2015
1	Cough 01/2015
1	Respiratory Sounds (Crackle) 01/2013
1	Respiratory Tract Infections (Respiratory Tract Infection) 12/2012
1	Nausea 10/2012
1	Tobacco Use Disorder (Nicotine Dependence) 10/2012

Drug/Important Bio-Agent (IBA)

28	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2022 - 03/2002
17	Bronchodilator Agents (Bronchodilators)IBA 01/2022 - 03/2002
13	indacaterolIBA 01/2021 - 07/2011
12	Glycopyrrolate (Glycopyrronium Bromide)FDA LinkGeneric 01/2021 - 10/2013
12	Fluticasone (Cutivate)FDA LinkGeneric 01/2020 - 03/2002
11	Muscarinic AntagonistsIBA 10/2021 - 10/2013
10	Salmeterol Xinafoate (Serevent)FDA Link 01/2019 - 03/2002
9	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2016
8	aclidinium bromideIBA 10/2021 - 08/2015
7	Tiotropium Bromide (Spiriva)FDA Link 01/2019 - 03/2007
6	GoldIBA 04/2021 - 01/2012
6	Formoterol Fumarate (Oxis)FDA Link 01/2021 - 08/2010
5	Fluticasone-Salmeterol Drug Combination (Advair)FDA Link 10/2020 - 03/2002
4	omega-Chloroacetophenone (Mace)IBA 10/2021 - 01/2018
4	Omalizumab (Xolair)FDA Link 05/2021 - 07/2006
4	mepolizumabIBA 05/2021 - 01/2019
4	Cholinergic Antagonists (Anticholinergics)IBA 01/2020 - 05/2002
4	Peptide Hydrolases (Proteases)FDA Link 01/2018 - 01/2005
3	Pharmaceutical PreparationsIBA 01/2022 - 06/2019
3	AllergensIBA 01/2020 - 12/2012
3	alpha 1-Antitrypsin (alpha 1 Antitrypsin)IBA 01/2018 - 07/2015
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 02/2009 - 02/2003
2	Immunoglobulin E (IgE)IBA 01/2022 - 07/2006
2	Mometasone Furoate (Nasonex)FDA LinkGeneric 01/2021 - 10/2020
2	Acetates (Acetic Acid Esters)FDA Link 01/2021 - 10/2020
2	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA 10/2020 - 01/2019
2	PeriostinIBA 01/2020 - 10/2016
2	indacaterol-glycopyrronium combinationIBA 01/2015 - 10/2013
2	SmokeIBA 04/2014 - 12/2012
2	Budesonide (Pulmicort)FDA LinkGeneric 08/2010 - 01/2003
2	SteroidsIBA 04/2010 - 03/2009
2	montelukast (Singulair)FDA Link 02/2009 - 10/2003
2	Leukotriene Antagonists (Leukotriene Receptor Antagonists)IBA 02/2009 - 10/2003
2	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 10/2003 - 02/2003
1	Particulate MatterIBA 01/2022
1	Nitrogen DioxideIBA 01/2022
1	dupilumabIBA 01/2022
1	AntibodiesIBA 01/2022
1	Cholinergic Agents (Cholinergics)IBA 10/2021
1	IridiumIBA 10/2020
1	Bromhexine (Bisolvon)IBA 01/2020
1	DNA (Deoxyribonucleic Acid)IBA 10/2019
1	Methacholine Chloride (Methacholine)FDA Link 10/2019
1	4-amino-4'-hydroxylaminodiphenylsulfone (HADS)IBA 01/2019
1	Insulin (Novolin)FDA Link 11/2017
1	Biological ProductsIBA 01/2017
1	Biological FactorsIBA 01/2017
1	Monoclonal AntibodiesIBA 10/2016
1	lebrikizumabIBA 10/2016
1	GlucocorticoidsIBA 01/2016
1	bis(p-chlorophenyl)acetic acid (DDA)IBA 01/2013
1	Air Pollutants (Pollutants, Air)IBA 12/2012
1	Varenicline (Chantix)FDA Link 10/2012
1	RetinoidsIBA 08/2012
1	Retinoic Acid Receptors (Retinoic Acid Receptor)IBA 08/2012
1	PalovaroteneIBA 08/2012
1	LipidsIBA 06/2012

Therapy/Procedure

26	Therapeutics 10/2021 - 03/2002
5	Nebulizers and Vaporizers (Inhaler) 01/2021 - 03/2002
2	Ambulatory Care (Outpatient Care) 01/2018 - 03/2006
2	Biological Therapy 01/2017 - 04/2009
2	Dry Powder Inhalers 01/2012 - 01/2011
1	Critical Care (Surgical Intensive Care) 12/2020
1	Artificial Respiration (Mechanical Ventilation) 01/2020
1	Lung Transplantation 07/2015
1	Pneumonectomy (Lung Volume Reduction) 07/2015